Balancing Bleeding and Clotting

Bleeding and Clotting Disorders

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental ...

Balancing Bleeding and Clotting: The Known Unknowns of Mechanically Assisted Circulation.

Bleeding and clotting disorders in pediatric liver disease.

The coagulopathy of liver disease in pediatric patients presents an unusual set of challenges. Little pediatric data have been published, so this review is based largely on adult studies. There is a precarious balance between deficiencies of clotting factors and anticoagulation factors in liver disease that result in abnormal prothrombin time (PT) and activated partial thromboplastin time (aPTT...

Clotting factor XIII and desmopressin improve hemostasis in uncontrolled bleeding.

PURPOSE To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding. METHODS Fifty-four rabbits were randomized in nine groups: G1: Sham; G2: FXIII and normotensive resuscitation (NBP); G3: FXIII and permissive hypotension (PH) (MAP 60% baseline); G4: FXIII/DDAVP/NBP; G5: FXIII/DDAVP/PH; G6: NBP only; G7: FXIII no hemorrhag...

Balancing bleeding in brain metastases.

In this issue of Blood, Donato et al report that treatment of venous thromboembolism (VTE) with anticoagulation does not increase the risk of intracranial hemorrhage (ICH) in patients with solid tumors metastatic to the brain.